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Not run on Windows Vista.

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Best free antivirus out there -- works great on 98se through Vista (no 64-bit at the moment, I believe, but I'm sure it's coming)

I've replaced Norton/McAfee with Antivir on literally dozens of different pcs, and there have never been any problems I've heard of, whether incompatibility or infection. Can be over-zealous with heuristic protections, but if you trust the 'supposedly' infected software just create an exception (usually fixed in the definitions in a day or two)

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