With easy to access PCIe locks like the ones on the GA-P35-DS4, it doesn't matter if the videocard has a large double-slot heatsink, access is unimpeded. If you have to struggle with a screwdriver to release an obscured PCIe slot lock and get the videocard out, you may end up with an electrical short or snapped component. Just a thought, it's not like PCSTATS has had hands on experience with 200-odd motherboards or anything... oh wait! We have. :-)