A free compatibility list for Windows compatible operating systems https://www.ntcompatible.com/compatibility/ 1 2000-04-01T10:00:00+00:00 Epson PhotoPC 650 1/compatibility/report/epson-photopc-650/ Epson Epson Hardware/General Windows 2000 2000-04-01T10:00:00+00:00 Anonymous Windows 2000 5 Epson claims this camera is not supported under Windows 2000. However, if you go to the Lexar Media site and download the USB drivers you can use the USB download feature of the camera (I've never tried serial). Download drivers https://www.gnu.org/licenses/lgpl-3.0.html