Very shortly into the game, Clarke becomes separated from his team, and under siege from a series of bizarre and deadly creatures that infest the station. Armed with a simple plasma cutter weapon, Clarke must not only survive the aliens that roam the station but he must complete several tasks such as restoring the ships tram service and unblocking vital areas of the ship.

As the story unfolds, Clarke is able to upgrade his arsenal through the collection and use of power nodes, and through collecting credits, is able to purchase new weapons such as military grade rifles and flamethrowers to fight off the Necromorphs.